Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Xu, K; Yin, N; Peng, M; Stamatiades, EG; Chhangawala, S; Shyu, A; Li, P; Zhang, X; Do, MH; Capistrano, KJ; Chou, C; Leslie, CS; Li, MO

Li, MO (corresponding author), Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA.; Li, MO (corresponding author), Cornell Univ, Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Grad Program, New York, NY 10065 USA.; Li, MO (corresponding author), Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, New York, NY 10065 USA.

IMMUNITY, 2021; 54 (5): 976

Abstract

Aerobic glycolysis-the Warburg effect-converts glucose to lactate via the enzyme lactate dehydrogenase A (LDHA) and is a metabolic feature of effector......

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