Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

Asrani, KH; Farelli, JD; Stahley, MR; Miller, RL; Cheng, CJ; Subramanian, RR; Brown, JM

Subramanian, RR (reprint author), Alex Pharmaceut Inc, Cambridge, MA USA.

RNA BIOLOGY, 2018; 15 (6): 756

Abstract

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges inc......

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