Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38

Jin, C; Zhang, QM; Lu, W

Lu, W (reprint author), East China Normal Univ, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017; 132 ( ): 135

Abstract

We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl) methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). I......

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