Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence

Li, YP; Peng, ZYF; Wang, CL; Li, L; Leng, YP; Chen, RF; Yuan, H; Zhou, SH; Zhang, Z; Chen, AF

Chen, AF (reprint author), Univ Pittsburgh, Sch Med, Dept Surg, 200 Lothrup St, Pittsburgh, PA 15213 USA.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018; 315 (3): H571

Abstract

Endothelial cell senescence is regarded as a vital characteristic of cardiovascular diseases. Elevated palmitate (PA) is an independent risk factor of......

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