Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus

D'Souza, SS; Kumar, A; Weinfurter, J; Park, MA; Maufort, J; Tao, LH; Kang, H; Dettle, ST; Golos, T; Thomson, JA; Reynolds, MR; Slukvin, I

Slukvin, I (通讯作者)，Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA.;Slukvin, I (通讯作者)，Univ Wisconsin, Dept Cell & Regenerat Biol, Madison, WI 53706 USA.;Slukvin, I (通讯作者)，Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53792 USA.

STEM CELL REPORTS, 2022; 17 (4): 953

Abstract

Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have shown promise for AIDS therapy. A renewable source of HIV-re......

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