Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)

Rew, Y; Du, XH; Eksterowicz, J; Zhou, HY; Jahchan, N; Zhu, LS; Yan, XL; Kawai, H; McGee, LR; Medina, JC; Huang, O; Chen, C; Zavorotinskaya, T; Sutimantanapi, D; Waszczuk, J; Jackson, E; Huang, E; Ye, QP; Fantin, VR; Sun, DQ

Rew, Y; Sun, DQ (reprint author), ORIC Pharmaceut, 240 East Grand Ave,Fl2, San Francisco, CA 94080 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (17): 7767

Abstract

The glucocorticoid receptor (GR) has been linked to therapy resistance across a wide range of cancer types. Preclinical data suggest that antagonists ......

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