Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator

Hobson, AD; McPherson, MJ; Hayes, ME; Goess, C; Li, X; Zhou, J; Wang, ZY; Yu, YJ; Yang, JD; Sun, L; Zhang, Q; Qu, P; Yang, S; Hernandez, A; Bryant, SH; Mathieu, SL; Bischoff, AK; Fitzgibbons, J; Santora, LC; Wang, L; Fettis, MM; Li, XF; Marvin, CC; Wang, Z; Patel, MV; Schmidt, DL; Li, TM; Randolph, JT; Henry, RF; Graff, C; Tian, Y; Aguirre, AL; Shrestha, A

Hobson, AD (通讯作者)，AbbVie Biores Ctr, Worcester, MA 01605 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (23): 15893

Abstract

Using a convergent synthetic route to enable multiple points of diversity, a series of glucocorticoid receptor modulators (GRM) were profiled for pote......

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