Electrostatic mechanism of V600E mutation-induced B-Raf constitutive activation in colorectal cancer: molecular implications for the selectivity difference between type-I and type-II inhibitors

Liu, T; Wang, ZS; Guo, P; Ding, N

Ding, N (reprint author), Weifang Med Univ, Weifang Peoples Hosp, Dept Anorectal Surg, Weifang 261041, Peoples R China.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2019; 48 (1): 73

Abstract

The oncogenic mutation V600E in B-Raf activation loop (A-loop) has been frequently observed to cause drug resistance in colorectal cancer chemotherapy......

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