Intellectual disability-associated gene ftsj1 is responsible for 2 '-O-methylation of specific tRNAs

Li, J; Wang, YN; Xu, BS; Liu, YP; Zhou, M; Long, T; Li, H; Dong, H; Nie, Y; Chen, PR; Wang, ED; Liu, RJ

Wang, ED (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Mol Biol,CAS Ctr Excellence Mol Cel, Shanghai, Peoples R China.; Wang, ED; Liu, RJ (corresponding author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China.

EMBO REPORTS, 2020; 21 (8):

Abstract

tRNA modifications at the anti-codon loop are critical for accurate decoding. FTSJ1 was hypothesized to be a human tRNA 2 '-O-methyltransferase. tRNA(......

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