Copper Chelation Inhibits BRAF(V600E)-Driven Melanomagenesis and Counters Resistance to BRAF(V600E) and MEK1/2 Inhibitors

Brady, DC; Crowe, MS; Greenberg, DN; Counter, CM

Counter, CM (reprint author), Duke Univ, Med Ctr, DUMC 3813, Durham, NC 27710 USA.; Brady, DC (reprint author), Univ Penn, 421 Curie Blvd,612 BRB2-3, Philadelphia, PA 19104 USA.

CANCER RESEARCH, 2017; 77 (22): 6240

Abstract

MEK1/2 and BRAF(V600E) inhibitors are used to treat BRAF(V600E)-positive melanoma, with other cancers under evaluation. Genetic perturbation of copper......

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