Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

De Luca, L; Mancuso, F; Ferro, S; Buemi, MR; Angeli, A; Del Prete, S; Capasso, C; Supuran, CT; Gitto, R

De Luca, L; Gitto, R (reprint author), Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Viale Annunziata, I-98168 Messina, Italy.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018; 143 (): 276

Abstract

Coumarin derivatives are a peculiar class of inhibitors of the family of metalloenzymes carbonic anhydrases (CA, EC 4.2.1.1). Several coumarins displa......

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