Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells

Geersing, A; de Vries, RH; Jansen, G; Rots, MG; Roelfes, G

Roelfes, G (reprint author), Univ Groningen, Stratingh Inst Chem, Nijenborgh 4, NL-9747 AG Groningen, Netherlands.; Rots, MG (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019; 29 (15): 1922

Abstract

A major challenge in the application of cytotoxic anti-cancer drugs is their general lack of selectivity, which often leads to systematic toxicity due......

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