Discovery of pan-IAP degraders via a CRBN recruiting mechanism

Park, S; Kim, D; Lee, W; Cho, JH; Kim, S; Lee, GS; Ha, JD; Moon, JH; Kim, JA; Kim, JH; Kim, HJ

Kim, JH (通讯作者),Korea Res Inst Biosci & Biotechnol KRIBB, Dis Target Struct Res Ctr, Daejeon 34141, South Korea.;Kim, HJ (通讯作者),Korea Res Inst Chem Technol, Data Convergence Drug Res Ctr, Therapeut & Biotechnol Div, Daejeon 34114, South Korea.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 245 ():

Abstract

Inhibitors of apoptosis proteins (IAPs), defined by the presence of baculovirus IAP repeat (BIR) protein domain, are critical regulators of cell survi......

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