Inhibition of Interleukin-1 beta by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease

Ridker, PM; MacFadyen, JG; Glynn, RJ; Koenig, W; Libby, P; Everett, BM; Lefkowitz, M; Thuren, T; Cornel, JH

Ridker, PM (reprint author), Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, 900 Commonwealth Ave, Boston, MA 02215 USA.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018; 71 (21): 2405

Abstract

BACKGROUND Inflammation contributes to chronic kidney disease (CKD), in part mediated through activation of interleukin (IL)-1 beta by the NLRP3 infla......

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