CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation

Lingel, H; Wissing, J; Arra, A; Schanze, D; Lienenklaus, S; Klawonn, F; Pierau, M; Zenker, M; Jansch, L; Brunner-Weinzierl, MC

Jansch, L (reprint author), Helmholtz Ctr Infect Res, Dept Mol Struct Biol, Inhoffenstr 7, D-38124 Braunschweig, Germany.; Brunner-Weinzierl, MC (reprint author), Otto von Guericke Univ, Univ Hosp, Dept Expt Pediat, Leipziger Str 44, D-39120 Magdeburg, Ge

CELL DEATH AND DIFFERENTIATION, 2017; 24 (10): 1739

Abstract

The blockade of inhibitory receptors such as CTLA-4 (CD152) is being used as immune-checkpoint therapy, offering a powerful strategy to restore effect......

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