Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization

Camviel, N; Wolf, B; Croce, G; Gfeller, D; Zoete, V; Arber, C

Arber, C (通讯作者)，Lausanne Univ Hosp CHUV, Dept Oncol UNIL CHUV, Lausanne, Switzerland.;Arber, C (通讯作者)，Ludwig Inst Canc Res, Lausanne Branch, Lausanne, Switzerland.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022; 10 (11):

Abstract

BackgroundChimeric antigen receptor (CAR) T cell therapy targeting B cell maturation antigen (BCMA) on multiple myeloma (MM) produces fast but not lon......

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