Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc

Zhang, JY; Ren, PW; Xu, D; Liu, XF; Liu, ZZ; Zhang, CF; Li, Y; Wang, LJ; Du, XJ; Xing, BC

Xing, BC (reprint author), Peking Univ, Canc Hosp & Inst, Hepatopancreatobiliary Surg Dept 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fu Cheng Rd, Beijing 100142, Peoples R China.; Du, XJ (reprint author), Peking Univ, Sch Basic Med Sci, Dep

CANCER LETTERS, 2019; 440 (): 106

Abstract

Nucleolar protein hUTP14a is required for 18S rRNA processing and promotes p53 degradation. Here, we report that hUTP14a stabilizes c-Myc in colorecta......

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