B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

Taylor, J; Wilmore, S; Marriot, S; Rogers-Broadway, KR; Fell, R; Minton, AR; Branch, T; Ashton-Key, M; Coldwell, M; Stevenson, FK; Forconi, F; Steele, AJ; Packham, G; Yeomans, A

Packham, G (通讯作者)，Southampton Gen Hosp, Canc Res UK Ctr, Somers Bldg, Southampton SO16 6YD, Hants, England.

CELLULAR SIGNALLING, 2022; 94 ():

Abstract

B-cell receptor (BCR) signaling plays a major role in the pathogenesis of B-cell malignancies and is an established target for therapy, including in c......

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