Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

McCoull, W; Cheung, T; Anderson, E; Barton, P; Burgess, J; Byth, K; Cao, Q; Castald, MP; Chen, H; Chiarparin, E; Carbajo, RJ; Code, E; Cowan, S; Davey, PR; Ferguson, AD; Fillery, S; Fuller, NO; Gao, N; Hargreaves, D; Howard, MR; Hu, J; Kawatkar, A; K

McCoull, W (reprint author), AstraZeneca, IMED Biotech Unit, Oncol & Discovery Sci, 310 Cambridge Sci Pk,Milton Rd, Cambridge CB4 0WG, England.

ACS CHEMICAL BIOLOGY, 2018; 13 (11): 3131

Abstract

B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to eval......

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