Depletion of AADC activity in caudate nucleus and putamen of Parkinson's disease patients; implications for ongoing AAV2-AADC gene therapy trial

Ciesielska, A; Samaranch, L; San Sebastian, W; Dickson, DW; Goldman, S; Forsayeth, J; Bankiewicz, KS

Bankiewicz, KS (reprint author), Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA.

PLOS ONE, 2017; 12 (2):

Abstract

In Parkinson's disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine ......

Full Text Link