Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

Struijf, EM; Becerra, KI; Ruyken, M; de Haas, CJC; van Oosterom, F; Siere, DY; van Keulen, JE; Heesterbeek, DAC; Dolk, E; Heukers, R; Bardoel, BW; Gros, P; Rooijakkers, SHM

Rooijakkers, SHM (通讯作者),Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (8):

Abstract

The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory disease......

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