Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

Hanf, KJM; Arndt, JW; Liu, YT; Gong, BJ; Rushe, M; Sopko, R; Massol, R; Smith, B; Gao, Y; Dalkilic-Liddle, I; Lee, X; Mojta, S; Shao, ZH; Mi, S; Pepinsky, RB

Hanf, KJM (corresponding author), Biogen, 225 Binney St, Cambridge, MA 02142 USA.

MABS, 2020; 12 (1):

Abstract

LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockad......

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