Small change for big improvement in the preparation of the key intermediate N1, N3-disubstituted 1,3,5-triazone of ensitrelvir

Hu, W; Liu, YC; Zhang, X; Zheng, PP; Yang, FF; Guo, GY; Xie, X; Huang, JZ; Chen, WM

Huang, JZ; Chen, WM (通讯作者),Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Peoples R China.;Huang, JZ; Chen, WM (通讯作者),Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou 341000, Peoples R China.

RSC ADVANCES, 2023; 13 (6): 3688

Abstract

In this study, the key intermediate N-1, N-3-disubstituted 1,3,5-triazone of ensitrelvir fumaric acid, approved in Japan for the treatment of SARS-CoV......

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