Exceptional Response to Temsirolimus in a Metastatic Clear Cell Renal Cell Carcinoma With an Early Novel MTOR-Activating Mutation

Rodriguez-Moreno, JF; Apellaniz-Ruiz, M; Roldan-Romero, JM; Duran, I; Beltran, L; Montero-Conde, C; Cascon, A; Robledo, M; Garcia-Donas, J; Rodriguez-Antona, C

Garcia-Donas, J (reprint author), Clara Campal Comprehens Canc Ctr, Oncol Unit, Ona St 10, Madrid 28050, Spain.; Rodriguez-Antona, C (reprint author), Spanish Natl Canc Res Ctr CNIO, Hereditary Endocrine Canc Grp, Melchor Fernandez Almagro 3, Madrid 28029

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017; 15 (11): 1310

Abstract

mTOR pathway inhibitors are important drugs for the treatment of advanced renal cell carcinoma (RCC). However, no valid predictive markers have been i......

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