Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2

Thientosapol, ES; Sharbeen, G; Lau, KKE; Bosnjak, D; Durack, T; Stevanovski, I; Weninger, W; Jolly, CJ

Jolly, CJ (reprint author), Royal Prince Alfred Hosp, Centenary Inst, Camperdown, NSW 2050, Australia.

NUCLEIC ACIDS RESEARCH, 2017; 45 (6): 3146

Abstract

AID deaminates C to U in either strand of Ig genes, exclusively producing C:G/G:C to T:A/A:T transition mutations if U is left unrepaired. Error-prone......

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