Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response

Bernhardt, M; Novak, D; Assenov, Y; Orouji, E; Knappe, N; Weina, K; Reith, M; Larribere, L; Gebhardt, C; Plass, C; Umansky, V; Utikal, J

Utikal, J (reprint author), German Canc Res Ctr, Skin Canc Unit G300, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.; Utikal, J (reprint author), Ruprecht Karl Univ Heidelberg, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, D-68167 Mannheim

STEM CELL REPORTS, 2017; 8 (5): 1379

Abstract

A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is present in 45%-60% of patients and acts as a key driver ......

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