An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing

Wong, RMW; Balachandran, A; Cheung, PK; Cheng, R; Pan, Q; Stoilov, P; Harrigan, PR; Blencowe, BJ; Branch, DR; Cochrane, A

Wong, RMW (corresponding author), Univ Toronto, Dept Med, Toronto, ON, Canada.; Wong, RMW (corresponding author), Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.; Cochrane, A (corresponding author), Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.; Cochrane, A (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.

PLOS PATHOGENS, 2020; 16 (2):

Abstract

The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling t......

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