Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling

Zhao, X; Zhang, Q; Wang, YY; Li, SP; Yu, XY; Wang, BT; Wang, XM

Zhao, X (corresponding author), Zhengzhou Univ, Henan Breast Canc Ctr, Dept Breast Dis, Affiliated Canc Hosp, Zhengzhou 450008, Peoples R China.; Zhao, X (corresponding author), Henan Canc Hosp, Zhengzhou 450008, Peoples R China.; Wang, XM (corresponding author), Tianjin Nankai Hosp, Inst Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Orga, 6 Changjiang Rd, Tianjin 300100, Peoples R China.

ANNALS OF TRANSLATIONAL MEDICINE, 2021; 9 (13):

Abstract

Y Background: Oridonin is a diterpenoid isolated from Rabdosia rubescens that has potent anticancer activity. This study set out to investigate the an......

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