ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and A beta production independently of their cholesterol efflux capacity

Dafnis, I; Raftopoulou, C; Mountaki, C; Megalou, E; Zannis, VI; Chroni, A

Chroni, A (reprint author), Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Athens 15341, Greece.

BIOCHEMICAL JOURNAL, 2018; 475 (): 1839

Abstract

The beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-beta peptide (A beta), which is central to the p......

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