CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels

Chini, CCS; Peclat, TR; Warner, GM; Kashyap, S; Espindola-Netto, JM; de Oliveira, GC; Gomez, LS; Hogan, KA; Tarrago, MG; Puranik, AS; Agorrody, G; Thompson, KL; Dang, K; Clarke, S; Childs, BG; Kanamori, KS; Witte, MA; Vidal, P; Kirkland, AL; De Cecco, M; Chellappa, K; McReynolds, MR; Jankowski, C; Tchkonia, T; Kirkland, JL; Sedivy, JM; van Deursen, JM; Baker, DJ; van Schooten, W; Rabinowitz, JD; Baur, JA; Chini, EN

Chini, EN (corresponding author), Mayo Clin, Signal Transduct & Mol Nutr Lab, Kogod Aging Ctr, Dept Anesthesiol & Perioperat Med,Coll Med, Rochester, MN 55905 USA.

NATURE METABOLISM, 2020; 2 (11):

Abstract

Decreased NAD(+) levels have been shown to contribute to metabolic dysfunction during aging. NAD(+) decline can be partially prevented by knockout of ......

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