Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

Mentrup, T; Theodorou, K; Cabrera-Cabrera, F; Hethig, AO; Happ, K; Gijbels, M; Gradtke, AC; Rabe, B; Fukumori, A; Steiner, H; Tholey, A; Fluhrer, R; Donners, M; Schroder, B

Schroder, B (reprint author), Tech Univ Dresden, Inst Physiol Chem, Dresden, Germany.; Schroder, B (reprint author), Christian Albrechts Univ Kiel, Biochem Inst, Kiel, Germany.

JOURNAL OF EXPERIMENTAL MEDICINE, 2019; 216 (4): 807

Abstract

The lectin-like oxidized LDL receptor 1 (LOX-1) is a key player in the development of atherosclerosis. LOX-1 promotes endothelial activation and dysfu......

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