A Novel TrxR1 Inhibitor Regulates NK and CD8+T Cell Infiltration and Cytotoxicity, Enhancing the Efficacy of Anti-PD-1 Immunotherapy against Hepatocarcinoma

Su, XX; Yin, HW; Bai, M; Liu, JY; Liu, RY; Zeng, HH; Wen, JH

Wen, JH (通讯作者)，Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, 38 Xueyuan Rd, Beijing 100191, Peoples R China.;Wen, JH (通讯作者)，Peking Univ Hlth Sci Ctr, Stem Cell Res Ctr, Sch Basic Med Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China.;Zeng, HH (通讯作者)，Peking Univ, Sch Pharamaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.

JOURNAL OF IMMUNOLOGY, 2023; 210 (5): 681

Abstract

Hepatocellular carcinoma (HCC) has the third highest cancer-related mortality rate globally. The immunosuppressive microenvironment of HCC limits effe......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索