Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide

Hata, S; Saito, H; Kakiuchi, T; Fukumoto, D; Yamamoto, S; Kasuga, K; Kimura, A; Moteki, K; Abe, R; Adachi, S; Kinoshita, S; Yoshizawa-Kumagaye, K; Nishio, H; Saito, T; Saido, TC; Yamamoto, T; Nishimura, M; Taru, H; Sobu, Y; Ohba, H; Nishiyama, S; Harada, N; Ikeuchi, T; Tsukada, H; Ouchi, Y; Suzuki, T

Suzuki, T (通讯作者)，Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Neurosci, Sapporo, Japan.;Suzuki, T (通讯作者)，Hokkaido Univ, Grad Sch Pharmaceut Sci, Adv Prevent & Res Lab Dementia, Sapporo, Japan.;Ouchi, Y (通讯作者)，Hamamatsu Univ Sch Med, Preeminent Med Educ & Res Ctr, Dept Biofunct Imaging, Hamamatsu, Japan.

EMBO MOLECULAR MEDICINE, 2023; 15 (5):

Abstract

We propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3-Alc beta 37 is generated from the neuronal protein alcadein beta ......

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