A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia

Xu, X; Wang, J; Tong, T; Zhang, WW; Wang, J; Ma, WW; Wang, SQ; Zhou, DH; Wu, J; Jiang, LJ; Zhao, M

Xu, X; Wu, J; Jiang, LJ (通讯作者)，Sun Yat sen Univ, Sun Yat sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China.;Xu, X; Zhao, M (通讯作者)，Sun Yat sen Univ, Zhongshan Sch Med, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou, Guangdong, Peoples R China.;Wu, J (通讯作者)，Sun Yat sen Univ, Sch Biomed Engn, Key Lab Sensing Technol & Biomed Instrument Guangd, Guangzhou, Guangdong, Peoples R China.

HAEMATOLOGICA, 2022; 107 (10): 2344

Abstract

Chemotherapy is the primary treatment option for acute myeloid leukemia (AML), but leukemic stem cells (LSC) can sur-vive chemotherapy for disease rec......

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