A universal allosteric mechanism for G protein activation

Knight, KM; Ghosh, S; Campbell, SL; Lefevre, TJ; Olsen, RHJ; Smrcka, AV; Valentin, NH; Yin, GW; Vaidehi, N; Dohlman, HG

Dohlman, HG (corresponding author), Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA.; Vaidehi, N (corresponding author), City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Beckman Res Inst, Duarte, CA 91010 USA.

MOLECULAR CELL, 2021; 81 (7): 1384

Abstract

(G) proteins play a central role in signal transduction and pharmacology. Signaling is initiated by cell-surface receptors, which promote guanosine tr......

Full Text Link