ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

An, HY; Skelt, L; Notaro, A; Highley, JR; Fox, AH; La Bella, V; Buchman, VL; Shelkovnikova, TA

Buchman, VL; Shelkovnikova, TA (reprint author), Cardiff Univ, Sch Biosci, Sir Martin Evans Bldg,Museum Ave, Cardiff CF10 3AX, S Glam, Wales.

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2019; 7 ():

Abstract

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in......

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