Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity

Hori, Y; Aoki, N; Kuwahara, S; Hosojima, M; Kaseda, R; Goto, S; Iida, T; De, S; Kabasawa, H; Kaneko, R; Aoki, H; Tanabe, Y; Kagamu, H; Narita, I; Kikuchi, T; Saito, A

Saito, A (reprint author), Niigata Univ, Grad Sch Med & Dent Sci, Dept Appl Mol Med, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518510, Japan.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017; 28 (6): 1783

Abstract

Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical memb......

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