MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents

McDaniel, NK; Cummings, CT; Iida, M; Hulse, J; Pearson, HE; Vasileiadi, E; Parker, RE; Orbuch, RA; Ondracek, OJ; Welke, NB; Kang, GH; Davies, KD; Wang, XD; Frye, SV; Earp, HS; Harari, PM; Kimple, RJ; DeRyckere, D; Graham, DK; Wheeler, DL

Wheeler, DL (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, 1111 Highland Ave,WIMR 3159, Madison, WI 53705 USA.; Graham, DK (reprint author), Emory Univ, 201 Downman Dr, Atlanta, GA 30322 USA.

MOLECULAR CANCER THERAPEUTICS, 2018; 17 (11): 2297

Abstract

The TAM (TYRO3, AXL, MERTK) family receptor tyrosine kinases (RTK) play an important role in promoting growth, survival, and metastatic spread of seve......

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