Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

Castro, DRG; Mazuk, JR; Heine, EM; Simpson, D; Pinches, RS; Lozzi, C; Hoffman, K; Morrin, P; Mathis, D; Lebedev, MV; Nissley, E; Han, KH; Farmer, T; Merry, DE; Tong, Q; Pennuto, M; Montie, HL

Montie, HL (通讯作者)，Philadelphia Coll Osteopath Med, Dept Biomed Sci, Philadelphia, PA 19131 USA.

ISCIENCE, 2023; 26 (8):

Abstract

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by poly......

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