Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis

Sun, RQ; Zhang, ZY; Bao, RX; Guo, XZ; Gu, Y; Yang, WJ; Wei, JS; Chen, XY; Tong, LF; Meng, J; Zhong, C; Zhang, C; Zhang, JY; Sun, YP; Ling, C; Tong, XM; Yu, FX; Yu, HX; Qu, WF; Zhao, B; Guo, W; Qian, MX; Saiyin, HXG; Liu, Y; Liu, RH; Xie, C; Liu, WR; Xiong, Y; Guan, KL; Shi, YH; Wang, P; Ye, D

Wang, P; Ye, D (通讯作者),Fudan Univ, Huashan Hosp, Shanghai 200032, Peoples R China.;Wang, P; Ye, D (通讯作者),Fudan Univ, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab, Minist Sci & Technol, Shanghai 200032, Peoples R China.;Wang, P; Ye, D (通讯作者),Fudan Univ, Key Lab Metab & Mol Med, Minist Educ, Shanghai 200032, Peoples R China.;Wang, P; Ye, D (通讯作者),Fudan Univ, Mol & Cell Biol Lab, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China.;Shi, YH (通讯作者),Fudan Univ, Zhongsh

JOURNAL OF HEPATOLOGY, 2022; 77 (2): 453

Abstract

Background & Aims: The liver is a metabolically active organ and is also 'tolerogenic', exhibiting sophisticated mechanisms of immune regulation t......

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