Persistently Elevated mTOR Complex 1-S6 Kinase 1 Disrupts DARPP-32-Dependent D1 Dopamine Receptor Signaling and Behaviors

Lin, RZ; Learman, LN; Na, CH; Renuse, S; Chen, KT; Chen, PY; Lee, GH; Xiao, B; Resnick, SM; Troncoso, JC; Szumlinski, KK; Linden, DJ; Park, JM; Savonenko, A; Pandey, A; Worley, PF

Worley, PF (corresponding author), Johns Hopkins Univ, Sch Med, Solomon Snyder Dept Neurosci, Baltimore, MD 21205 USA.; Worley, PF (corresponding author), Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.

BIOLOGICAL PSYCHIATRY, 2021; 89 (11): 1058

Abstract

BACKGROUND: The serine-threonine kinase mTORC1 (mechanistic target of rapamycin complex 1) is essential for normal cell function but is aberrantly act......

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