AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9

Li, A; Tanner, MR; Lee, CM; Hurley, AE; De Giorgi, M; Jarrett, KE; Davis, TH; Doerfler, AM; Bao, G; Beeton, C; Lagor, WR

Bao, G (corresponding author), Rice Univ, Dept Bioengn, Houston, TX 77030 USA.; Beeton, C; Lagor, WR (corresponding author), Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA.

MOLECULAR THERAPY, 2020; 28 (6): 1432

Abstract

Adeno-associated viral (AAV) vectors are a leading candidate for the delivery of CRISPR-Cas9 for therapeutic genome editing in vivo. However, AAV-base......

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