Optimized Kilogram-Scale Synthesis and Impurity Identification of SHEN26 (ATV014) for Treating COVID-19

Chen, QS; Zhou, QF; Li, GG; Li, S; Li, YJ; Zhang, XM

Li, YJ; Zhang, XM (通讯作者)，Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies & Medi X Pingsh, Coll Sci, Dept Chem, Shenzhen 518000, Guangdong, Peoples R China.

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; ():

Abstract

SHEN26, a 5 '-cyclohexane-carboxylate prodrug of the nucleoside analog GS-441524, is a potent RdRp inhibitor currently undergoing phase III clinical t......

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