Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5

Zhao, ZF; Ruan, SS; Ma, XM; Feng, Q; Xie, ZS; Nie, Z; Fan, PN; Qian, MC; He, XR; Wu, SP; Zhang, YM; Zheng, XH

Wu, SP (corresponding author), Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, 229 Taibai Rd, Xian 710069, Peoples R China.; Wu, SP (corresponding author), Northwest Univ, Sch Pharm, Biomed Key Lab Shaanxi Prov, 229 Taibai Rd, Xian 710069, Peoples R China.

BIOMOLECULES, 2020; 10 (1):

Abstract

The voltage-gated potassium channel Kv1.5, which mediates the cardiac ultra-rapid delayed-rectifier (I-Kur) current in human cells, has a crucial role......

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