Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism

Tapio, J; Halmetoja, R; Dimova, EY; Maki, JM; Laitala, A; Walkinshaw, G; Myllyharju, J; Serpi, R; Koivunen, P

Koivunen, P (通讯作者)，Univ Oulu, Fac Biochem & Mol Med, Oulu Ctr Cell Matrix Res, Bioctr Oulu, Oulu, Finland.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2022; 298 (8):

Abstract

Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases (HIFP4Hs 1-3) are druggable targets in renal anemia, where panHIF-P4H inhibitors induce an erythr......

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