Development of a chemical probe against NUDT15

Zhang, SM; Desroses, M; Hagenkort, A; Valerie, NCK; Rehling, D; Carter, M; Wallner, O; Koolmeister, T; Throup, A; Jemth, AS; Almlof, I; Loseva, O; Lundback, T; Axelsson, H; Regmi, S; Sarno, A; Kramer, A; Pudelko, L; Brautigam, L; Rasti, A; Gottmann, M; Wiita, E; Kutzner, J; Schaller, T; Kalderen, C; Cazares-Korner, A; Page, BDG; Krimpenfort, R; Eshtad, S; Altun, M; Rudd, SG; Knapp, S; Scobie, M; Homan, EJ; Berglund, UW; Stenmark, P; Helleday, T

Helleday, T (corresponding author), Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden.; Helleday, T (corresponding author), Univ Sheffield, Dept Oncol & Metab, Weston Pk Canc Ctr, Sheffield, S Yorkshire, England.

NATURE CHEMICAL BIOLOGY, 2020; 16 (10): 1120

Abstract

The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabo......

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