MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

Qiu, ZJ; Lin, AP; Jiang, SL; Elkashef, SM; Myers, J; Srikantan, S; Sasi, B; Cao, JZ; Godley, LA; Rakheja, D; Lyu, YL; Zheng, SY; Madesh, M; Shiio, Y; Dahia, PLM; Aguiar, RCT

Aguiar, RCT (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Div Hematol & Med Oncol, Dept Med, San Antonio, TX 78229 USA.; Aguiar, RCT (corresponding author), Audie Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA.

CELL CHEMICAL BIOLOGY, 2020; 27 (5): 538

Abstract

Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into alpha KG. This contributes to cellular homeostasis in ......

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