Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry

Dickinson, MS; Miyazawa, T; McCool, RS; Keatinge-Clay, AT

Keatinge-Clay, AT (通讯作者),Univ Texas Austin, Dept Mol Biosci, 100 E 24th St, Austin, TX 78712 USA.

STRUCTURE, 2022; 30 (9): 1331

Abstract

The first domain of modular polyketide synthases (PKSs) is most commonly a ketosynthase (KS)-like enzyme, KSQ, that primes polyketide synthesis. Unlik......

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