A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its Multiple-Dose Pharmacokinetics in Beagle Dogs

Li, MZ; Qiang, W; Wen, Z; Li, LL; Wang, L; Cheng, ZN

Wang, L; Cheng, ZN (reprint author), Cent S Univ, Sch Pharmaceut Sci, Res Inst Drug Metab & Pharmacokinet, Changsha 410013, Hunan, Peoples R China.; Wang, L (reprint author), Cent S Univ, Sch Life Sci, Dept Cell Biol, Changsha 410013, Hunan, Peoples R Chi

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (3): 1147

Abstract

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment......

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