Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling

Li, S; Jang, H; Zhang, J; Nussinov, R

Nussinov, R (reprint author), Leidos Biomed Res Inc, Natl Canc Inst Frederick, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Frederick, MD 21702 USA.; Nussinov, R (reprint author), Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, I

STRUCTURE, 2018; 26 (3): 513

Abstract

K-Ras4B preferentially activates Raf-1. The high-affinity interaction of Ras-binding domain (RBD) of Raf with Ras was solved, but the relative positio......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索